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荒木飛呂彦為 Cell 繪製封面 / Hirohiko Araki drew cover art for Cell

這個圖中的 "替身" 名叫 "SCRAPPER," 是一種新發現的 ubiquitin ligase, 可以 ubiquitinates RIM1, 使後者被降解. SCRAPPER knock-out mice 的突觸會有超常的電生理活動, 且 RIM1 的量也會增加, 而這個生理效應可以用再表現 SCRAPPER 或是 knock-out 掉 RIM1 來達成. 茲引封面註釋的原文如下:

On the cover: Presynaptic plasticity is a fundamental, yet poorly understood, neural phenomenon that is thought to be the basis of learning and memory. In this issue, Yao et al. (pp. 943–957) identify a novel ubiquitin ligase named SCRAPPER, which is responsible for tuning of synaptic vesicle release probability. SCRAPPER ubiquitinates presynaptic active zone protein RIM1, triggering its proteasomal degradation. Neurons from the Scrapper-knockout mice have hyper electrophysiological activity and contained increased amount of RIM1, and these phenotypes could be rescued by re-expression of SCRAPPER or knockdown of RIM1. The results highlight the importance of protein degradation in the regulation of synaptic activity in vivo. On the cover, the purple SCRAPPER humanoid is putting blue heart-shaped ubiquitins on the red RIM creatures. Japanese manga artist Hirohiko Araki created the cover image with scientific direction from Drs. Setou and Ageta.

太感謝您了, 荒木老師. 也謝謝兩位研究人員 (瀬藤光利准教授與 Dr. Ageta... 漢字不明) 的指導, 以及 Cell 編輯們的創意.

Thank you very much, Araki-sensei. Also thanks for instructions from two researchers, as well as creative minds of Cell editors.

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